Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity.
Identifieur interne : 000080 ( Main/Exploration ); précédent : 000079; suivant : 000081Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity.
Auteurs : Yu Du [République populaire de Chine] ; Xiaokang Chen [République populaire de Chine] ; Yalu Guo [République populaire de Chine] ; Xiaojiang Zhang [République populaire de Chine] ; Houxiao Zhang [République populaire de Chine] ; Fangfang Li [République populaire de Chine] ; Guiyan Huang [République populaire de Chine] ; Yuling Meng [République populaire de Chine] ; Weixing Shan [République populaire de Chine]Source :
- The New phytologist [ 1469-8137 ] ; 2020.
Abstract
Pathogens secret a plethora of effectors into the host cell to modulate plant immunity. Analysing the role of effectors in altering the function of their host target proteins will reveal critical components of the plant immune system. Here we show that Phytophthora infestans RXLR effector PITG20303, a virulent variant of AVRblb2 (PITG20300) that escapes recognition by the resistance protein Rpi-blb2, suppresses PAMP-triggered immunity (PTI) and promotes pathogen colonization by targeting and stabilizing a potato MAPK cascade protein, StMKK1. Both PITG20300 and PITG20303 target StMKK1, as confirmed by multiple in vivo and in vitro assays, and StMKK1 was shown to be a negative regulator of plant immunity, as determined by overexpression and gene silencing. StMKK1 is a negative regulator of plant PTI, and the kinase activities of StMKK1 are required for its suppression of PTI and effector interaction. PITG20303 depends partially on MKK1, PITG20300 does not depend on MKK1 for suppression of PTI-induced reactive oxygen species burst, while the full virulence activities of nuclear targeted PITG20303 and PITG20300 are dependent on MKK1. Our results show that PITG20303 and PITG20300 target and stabilize the plant MAPK cascade signalling protein StMKK1 to negatively regulate plant PTI response.
DOI: 10.1111/nph.16861
PubMed: 32772378
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712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xiaojiang" sort="Zhang, Xiaojiang" uniqKey="Zhang X" first="Xiaojiang" last="Zhang">Xiaojiang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Houxiao" sort="Zhang, Houxiao" uniqKey="Zhang H" first="Houxiao" last="Zhang">Houxiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Li, Fangfang" sort="Li, Fangfang" uniqKey="Li F" first="Fangfang" last="Li">Fangfang Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Guiyan" sort="Huang, Guiyan" uniqKey="Huang G" first="Guiyan" last="Huang">Guiyan Huang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Yuling" sort="Meng, Yuling" uniqKey="Meng Y" first="Yuling" last="Meng">Yuling Meng</name><affiliation wicri:level="1"><nlm:affiliation>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000</wicri:regionArea><wicri:noRegion>341000</wicri:noRegion></affiliation></author><author><name sortKey="Shan, Weixing" sort="Shan, Weixing" uniqKey="Shan W" first="Weixing" last="Shan">Weixing Shan</name><affiliation wicri:level="1"><nlm:affiliation>China-USA Citrus Huanglongbing Joint Laboratory, 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wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Yalu" sort="Guo, Yalu" uniqKey="Guo Y" first="Yalu" last="Guo">Yalu Guo</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xiaojiang" sort="Zhang, Xiaojiang" uniqKey="Zhang X" first="Xiaojiang" last="Zhang">Xiaojiang Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Houxiao" sort="Zhang, Houxiao" uniqKey="Zhang H" first="Houxiao" last="Zhang">Houxiao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Li, Fangfang" sort="Li, Fangfang" uniqKey="Li F" first="Fangfang" last="Li">Fangfang Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Guiyan" sort="Huang, Guiyan" uniqKey="Huang G" first="Guiyan" last="Huang">Guiyan Huang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100</wicri:regionArea><wicri:noRegion>712100</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Yuling" sort="Meng, Yuling" uniqKey="Meng Y" first="Yuling" last="Meng">Yuling Meng</name><affiliation wicri:level="1"><nlm:affiliation>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000</wicri:regionArea><wicri:noRegion>341000</wicri:noRegion></affiliation></author><author><name sortKey="Shan, Weixing" sort="Shan, Weixing" uniqKey="Shan W" first="Weixing" last="Shan">Weixing Shan</name><affiliation wicri:level="1"><nlm:affiliation>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000</wicri:regionArea><wicri:noRegion>341000</wicri:noRegion></affiliation></author></analytic><series><title level="j">The New phytologist</title><idno type="eISSN">1469-8137</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathogens secret a plethora of effectors into the host cell to modulate plant immunity. Analysing the role of effectors in altering the function of their host target proteins will reveal critical components of the plant immune system. Here we show that Phytophthora infestans RXLR effector PITG20303, a virulent variant of AVRblb2 (PITG20300) that escapes recognition by the resistance protein Rpi-blb2, suppresses PAMP-triggered immunity (PTI) and promotes pathogen colonization by targeting and stabilizing a potato MAPK cascade protein, StMKK1. Both PITG20300 and PITG20303 target StMKK1, as confirmed by multiple in vivo and in vitro assays, and StMKK1 was shown to be a negative regulator of plant immunity, as determined by overexpression and gene silencing. StMKK1 is a negative regulator of plant PTI, and the kinase activities of StMKK1 are required for its suppression of PTI and effector interaction. PITG20303 depends partially on MKK1, PITG20300 does not depend on MKK1 for suppression of PTI-induced reactive oxygen species burst, while the full virulence activities of nuclear targeted PITG20303 and PITG20300 are dependent on MKK1. Our results show that PITG20303 and PITG20300 target and stabilize the plant MAPK cascade signalling protein StMKK1 to negatively regulate plant PTI response.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32772378</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1469-8137</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>09</Day></PubDate></JournalIssue><Title>The New phytologist</Title><ISOAbbreviation>New Phytol</ISOAbbreviation></Journal><ArticleTitle>Phytophthora infestans RXLR effector PITG20303 targets a potato MKK1 protein to suppress plant immunity.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/nph.16861</ELocationID><Abstract><AbstractText>Pathogens secret a plethora of effectors into the host cell to modulate plant immunity. Analysing the role of effectors in altering the function of their host target proteins will reveal critical components of the plant immune system. Here we show that Phytophthora infestans RXLR effector PITG20303, a virulent variant of AVRblb2 (PITG20300) that escapes recognition by the resistance protein Rpi-blb2, suppresses PAMP-triggered immunity (PTI) and promotes pathogen colonization by targeting and stabilizing a potato MAPK cascade protein, StMKK1. Both PITG20300 and PITG20303 target StMKK1, as confirmed by multiple in vivo and in vitro assays, and StMKK1 was shown to be a negative regulator of plant immunity, as determined by overexpression and gene silencing. StMKK1 is a negative regulator of plant PTI, and the kinase activities of StMKK1 are required for its suppression of PTI and effector interaction. PITG20303 depends partially on MKK1, PITG20300 does not depend on MKK1 for suppression of PTI-induced reactive oxygen species burst, while the full virulence activities of nuclear targeted PITG20303 and PITG20300 are dependent on MKK1. Our results show that PITG20303 and PITG20300 target and stabilize the plant MAPK cascade signalling protein StMKK1 to negatively regulate plant PTI response.</AbstractText><CopyrightInformation>© 2020 The Authors. New Phytologist © 2020 New Phytologist Trust.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3512-0200</Identifier><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xiaokang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Yalu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xiaojiang</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Houxiao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Fangfang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Horticulture, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Guiyan</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, 712100, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Yuling</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shan</LastName><ForeName>Weixing</ForeName><Initials>W</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-7286-4041</Identifier><AffiliationInfo><Affiliation>China-USA Citrus Huanglongbing Joint Laboratory, National Navel Orange Engineering Research Center, College of Life Sciences, Gannan Normal University, Ganzhou, 341000, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>2016M600818</GrantID><Agency>China Postdoctoral Science Foundation</Agency><Country></Country></Grant><Grant><GrantID>2019T120956</GrantID><Agency>China Postdoctoral Science Foundation</Agency><Country></Country></Grant><Grant><GrantID>2017BSHYDZZ63</GrantID><Agency>China Postdoctoral Science Foundation</Agency><Country></Country></Grant><Grant><GrantID>31561143007</GrantID><Agency>National Natural Science Foundation of China</Agency><Country></Country></Grant><Grant><GrantID>31701770</GrantID><Agency>National Natural Science Foundation of China</Agency><Country></Country></Grant><Grant><GrantID>CARS-09</GrantID><Agency>China Agricultural Research System</Agency><Country></Country></Grant><Grant><Agency>Northwest A&F University Scientific Research Fund for Advanced Talents and Young Talent Training Program</Agency><Country></Country></Grant><Grant><Agency>Shaanxi Province Science and Technology Fund</Agency><Country></Country></Grant><Grant><Agency>State Administration of Foreign Experts Affairs</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>New Phytol</MedlineTA><NlmUniqueID>9882884</NlmUniqueID><ISSNLinking>0028-646X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Phytophthora infestans
</Keyword><Keyword MajorTopicYN="N">MAPK cascade</Keyword><Keyword MajorTopicYN="N">effector targets</Keyword><Keyword MajorTopicYN="N">oomycete</Keyword><Keyword MajorTopicYN="N">pathogenicity</Keyword><Keyword MajorTopicYN="N">susceptibility</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32772378</ArticleId><ArticleId IdType="doi">10.1111/nph.16861</ArticleId></ArticleIdList><ReferenceList><Title>References</Title><Reference><Citation>Ah Fong AMV, Kim KS, Judelson HS. 2017. RNA-seq of life stages of the oomycete Phytophthora infestans reveals dynamic changes in metabolic, signal transduction, and pathogenesis genes and a major role for calcium signaling in development. BMC Genomics 18: 198.</Citation></Reference><Reference><Citation>Berriri S, Garcia AV, Freidit Frey N, Rozhon W, Pateyron S, Leonhardt N, Montillet JL, Leung J, Hirt H, Colcombet J. 2012. Constitutively active Mitogen-activated protein kinase versions reveal functions of Arabidopsis MPK4 in pathogen defense signaling. Plant Cell 24: 4281-4293.</Citation></Reference><Reference><Citation>Bi G, Zhou JM. 2017. MAP kinase signaling pathways: a hub of plant-microbe interactions. Cell Host & Microbe 21: 270-273.</Citation></Reference><Reference><Citation>Boevink PC, Wang X, McLellan H, He Q, Naqvi S, Armstrong MR, Zhang W, Hein I, Gilroy EM, Tian Z et al. 2016. A Phytophthora infestans RXLR effector targets plant PP1c isoforms that promote late blight disease. Nature Communications 7: 10311.</Citation></Reference><Reference><Citation>Bos JI, Armstrong MR, Gilroy EM, Boevink PC, Hein I, Taylor RM, Zhendong T, Engelhardt S, Vetukuri RR, Harrower B et al. 2010. Phytophthora infestans effector AVR3a is essential for virulence and manipulates plant immunity by stabilizing host E3 ligase CMPG1. Proceedings of the National Academy of Sciences, USA 107: 9909-9914.</Citation></Reference><Reference><Citation>Bouwmeester K, de Sain M, Weide R, Gouget A, Klamer S, Canut H, Govers F. 2011. The lectin receptor kinase LecRK-I.9 is a novel Phytophthora resistance component and a potential host target for a RXLR effector. PLoS Pathogens 7: e1001327.</Citation></Reference><Reference><Citation>Bozkurt TO, Schornack S, Win J, Shindo T, Ilyas M, Oliva R, Cano LM, Jones AM, Huitema E, van der Hoorn RA et al. 2011. Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface. Proceedings of the National Academy of Sciences, USA 108: 20832-20837.</Citation></Reference><Reference><Citation>Champouret N, Bouwmeester K, Rietman H, van der Lee T, Maliepaard C, Heupink A, van de Vondervoort PJ, Jacobsen E, Visser RG, van der Vossen EA et al. 2009. Phytophthora infestans isolates lacking class I ipiO variants are virulent on Rpi-blb1 potato. Molecular Plant-Microbe Interactions 22: 1535-1545.</Citation></Reference><Reference><Citation>Chen H, Zou Y, Shang Y, Lin H, Wang Y, Cai R, Tang X, Zhou JM. 2008. Firefly luciferase complementation imaging assay for protein-protein interactions in plants. Plant Physiology 146: 368-76.</Citation></Reference><Reference><Citation>Cheng BP, Yu XL, Ma ZC, Dong SM, Dou DL, Wang YC, Zheng XB. 2012. Phytophthora sojae effector Avh331 suppresses the plant defence response by disturbing the MAPK signalling pathway. Physiological and Molecular Plant Pathology 77: 1-9.</Citation></Reference><Reference><Citation>Cui HT, Wang YJ, Xue L, Chu JF, Yan CY, Fu JH, Chen MS, Innes RW, Zhou JM. 2010. Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP kinase 4. Cell Host & Microbe 7: 164-175.</Citation></Reference><Reference><Citation>Dagdas YF, Belhaj K, Maqbool A, Chaparro-Garcia A, Pandey P, Petre B, Tabassum N, Cruz-Mireles N, Hughes RK, Sklenar J et al. 2016. An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. eLife 5: e10856.</Citation></Reference><Reference><Citation>Du Y, Berg J, Govers F, Bouwmeester K. 2015b. Immune activation mediated by the late blight resistance protein R1 requires nuclear localization of R1 and the effector AVR1. New Phytologist 207: 735-747.</Citation></Reference><Reference><Citation>Du Y, Mpina MH, Birch PR, Bouwmeester K, Govers F. 2015a. Phytophthora infestans RXLR effector AVR1 interacts with exocyst component Sec5 to manipulate plant immunity. Plant Physiology 169: 1975-1990.</Citation></Reference><Reference><Citation>Eschen-Lippold L, Jiang XY, Elmore JM, Mackey D, Shan LB, Coaker G, Scheel D, Lee J. 2016. Bacterial AvrRpt2-like cysteine proteases block activation of the Arabidopsis Mitogen-activated protein kinases, MPK4 and MPK11. Plant Physiology 171: 2223-2238.</Citation></Reference><Reference><Citation>Fan G, Yang Y, Li T, Lu W, Du Y, Qiang X, Wen Q, Shan W. 2018. A Phytophthora capsici RXLR effector targets and inhibits a plant PPIase to suppress endoplasmic reticulum-mediated immunity. Molecular Plant 11: 1067-1083.</Citation></Reference><Reference><Citation>Feng F, Yang F, Rong W, Wu X, Zhang J, Chen S, He C, Zhou JM. 2012. A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature 485: 114-118.</Citation></Reference><Reference><Citation>Haas BJ, Kamoun S, Zody MC, Jiang RHY, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T et al. 2009. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature 461: 393-398.</Citation></Reference><Reference><Citation>Hardham AR, Cahill DM. 2010. The role of oomycete effectors in plant-pathogen interactions. Functional Plant Biology 37: 919-925.</Citation></Reference><Reference><Citation>Haverkort AJ, Boonekamp PM, Hutten R, Jacobsen E, Lotz LAP, Kessel GJT, Vossen JH, Visser RGF. 2016. Durable late blight resistance in potato through dynamic varieties obtained by cisgenesis: scientific and societal advances in the DuRPh Project. Potato Research 59: 35-66.</Citation></Reference><Reference><Citation>He P, Shan L, Lin NC, Martin GB, Kemmerling B, Nurnberger T, Sheen J. 2006. Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity. Cell 125: 563-575.</Citation></Reference><Reference><Citation>He Q, Naqvi S, McLellan H, Boevink PC, Champouret N, Hein I, Birch PRJ. 2018. Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70. Proceedings of the National Academy of Sciences, USA 115: E7834-E7843.</Citation></Reference><Reference><Citation>Hu T, Huang C, He Y, Castillo-Gonzalez C, Gui X, Wang Y, Zhang X, Zhou X. 2019. βC1 protein encoded in geminivirus satellite concertedly targets MKK2 and MPK4 to counter host defense. PLoS Pathogens 15: e1007728.</Citation></Reference><Reference><Citation>Ingle RA, Carstens M, Denby KJ. 2006. PAMP recognition and the plant-pathogen arms race. BioEssays 28: 880-889.</Citation></Reference><Reference><Citation>Jagodzik P, Tajdel-Zielinska M, Ciesla A, Marczak M, Ludwikow A. 2018. Mitogen-activated protein kinase cascades in plant hormone signaling. Frontiers in Plant Science 9: 1387.</Citation></Reference><Reference><Citation>Jing M, Guo B, Li H, Yang B, Wang H, Kong G, Zhao Y, Xu H, Wang Y, Ye W et al. 2016. A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins. Nature communications 7: 11685.</Citation></Reference><Reference><Citation>Jones JDG, Dangl JL. 2006. The plant immune system. Nature 444: 323-329.</Citation></Reference><Reference><Citation>Kale SD, Gu B, Capelluto DGS, Dou D, Feldman E, Rumore A, Arredondo FD, Hanlon R, Fudal I, Rouxel T et al. 2010. External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. Cell 142: 284-295.</Citation></Reference><Reference><Citation>King SR, McLellan H, Boevink PC, Armstrong MR, Bukharova T, Sukarta O, Win J, Kamoun S, Birch PR, Banfield MJ. 2014. Phytophthora infestans RXLR effector PexRD2 interacts with host MAPKKK epsilon to suppress plant immune signaling. Plant Cell 26: 1345-1359.</Citation></Reference><Reference><Citation>Kong L, Qiu XF, Kang JG, Wang Y, Chen H, Huang J, Qiu M, Zhao Y, Kong GH, Ma ZC et al. 2017. A Phytophthora effector manipulates host histone acetylation and reprograms defense gene expression to promote infection. Current Biology 27: 981-991.</Citation></Reference><Reference><Citation>Li B, Jiang S, Yu X, Cheng C, Chen S, Cheng Y, Yuan JS, Jiang D, He P, Shan L. 2015. Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity. Plant Cell 27: 839-856.</Citation></Reference><Reference><Citation>Li L, Kim P, Yu L, Cai G, Chen S, Alfano JR, Zhou JM. 2016. Activation-dependent destruction of a co-receptor by a Pseudomonas syringae effector dampens plant immunity. Cell Host & Microbe 20: 504-514.</Citation></Reference><Reference><Citation>Li T, Wang Q, Feng R, Li L, Ding L, Fan G, Li W, Du Y, Zhang M et al. 2019. Negative regulators of plant immunity derived from cinnamyl alcohol dehydrogenases are targeted by multiple Phytophthora Avr3a-like effectors. New Phytologist. doi:10.1111/nph.16139.</Citation></Reference><Reference><Citation>Li X, Zhang Y, Huang L, Ouyang Z, Hong Y, Zhang H, Li D, Song F. 2014. Tomato SlMKK2 and SlMKK4 contribute to disease resistance against Botrytis cinerea. BMC Plant Biology 14: 166.</Citation></Reference><Reference><Citation>Ling TF, Bellin D, Vandelle E, Imanifard Z, Delledonne M. 2017. Host-mediated S-Nitrosylation disarms the bacterial effector HopAI1 to reestablish immunity. Plant Cell 29: 2871-2881.</Citation></Reference><Reference><Citation>Long Y, Xie D, Zhao Y, Shi D, Yang W. 2019. BICELLULAR POLLEN 1 is a modulator of DNA replication and pollen development in Arabidopsis. New Phytologist 222: 588-603.</Citation></Reference><Reference><Citation>Lu W, Chu X, Li Y, Wang C, Guo X. 2013. Cotton GhMKK1 induces the tolerance of salt and drought stress, and mediates defence responses to pathogen infection in transgenic Nicotiana benthamiana. PLoS One 8: e68503.</Citation></Reference><Reference><Citation>Lu X, Xiong Q, Cheng T, Li QT, Liu XL, Bi YD, Li W, Zhang WK, Ma B, Lai YC et al. 2017. A PP2C-1 allele underlying a quantitative trait locus enhances soybean 100-seed weight. Molecular Plant 10: 670-684.</Citation></Reference><Reference><Citation>McLellan H, Boevink PC, Armstrong MR, Pritchard L, Gomez S, Morales J, Whisson SC, Beynon JL, Birch PR. 2013. An RXLR effector from Phytophthora infestans prevents re-localisation of two plant NAC transcription factors from the endoplasmic reticulum to the nucleus. PLoS Pathogens 9: e1003670.</Citation></Reference><Reference><Citation>Meijer HJG, Mancuso FM, Espadas G, Seidl MF, Chiva C, Govers F, Sabido E. 2014. Profiling the secretome and extracellular proteome of the potato late blight pathogen Phytophthora infestans. Molecular & Cellular Proteomics 13: 2101-2113.</Citation></Reference><Reference><Citation>Murphy F, He Q, Armstrong M, Giuliani LM, Boevink PC, Zhang W, Tian Z, Birch PRJ, Gilroy EM. 2018. The potato MAP3K StVIK is required for the Phytophthora infestans RXLR effector Pi17316 to promote disease. Plant Physiology 177: 398-410.</Citation></Reference><Reference><Citation>Oliva RF, Cano LM, Raffaele S, Win J, Bozkurt TO, Belhaj K, Oh SK, Thines M, Kamoun S. 2015. A recent expansion of the RXLR effector gene Avrblb2 is maintained in global populations of Phytophthora infestans indicating different contributions to virulence. Molecular Plant-Microbe Interactions 28: 901-912.</Citation></Reference><Reference><Citation>Qiao Y, Shi J, Zhai Y, Hou Y, Ma W. 2015. Phytophthora effector targets a novel component of small RNA pathway in plants to promote infection. Proceedings of the National Academy of Sciences, USA 112: 5850-5855.</Citation></Reference><Reference><Citation>Ren Y, Armstrong M, Qi Y, McLellan H, Zhong C, Du B, Birch PRJ, Tian Z. 2019. Phytophthora infestans RXLR effectors target parallel steps in an immune signal transduction pathway. Plant Physiology 180: 2227-2239.</Citation></Reference><Reference><Citation>Saunders DGO, Breen S, Win J, Schornack S, Hein I, Bozkurt TO, Champouret N, Vleeshouwers VGAA, Birch PRJ, Gilroy EM et al. 2012. Host protein BSL1 associates with Phytophthora infestans RXLR effector AVR2 and the Solanum demissum immune receptor R2 to mediate disease resistance. Plant Cell 24: 3420-3434.</Citation></Reference><Reference><Citation>Tameling WIL, Baulcombe DC. 2007. Physical association of the NB-LRR resistance protein Rx with a Ran GTPase-activating protein is required for extreme resistance to Potato virus X. Plant Cell 19: 1682-1694.</Citation></Reference><Reference><Citation>Teper D, Girija AM, Bosis E, Popov G, Savidor A, Sessa G. 2018. The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling. PLoS Pathogens 14: e1006880.</Citation></Reference><Reference><Citation>Tomczynska I, Stumpe M, Mauch F. 2018. A conserved RXLR effector interacts with host RABA-type GTPases to inhibit vesicle-mediated secretion of antimicrobial proteins. The Plant Journal 95: 187-203.</Citation></Reference><Reference><Citation>Turnbull D, Yang L, Naqvi S, Breen S, Welsh L, Stephens J, Morris J, Boevink PC, Hedley PE, Zhan J et al. 2017. RXLR effector AVR2 up-regulates a brassinosteroid responsive bHLH transcription factor to suppress immunity. Plant Physiology 174: 356-369.</Citation></Reference><Reference><Citation>Ueno Y, Yoshida R, Kishi-Kaboshi M, Matsushita A, Jiang CJ, Goto S, Takahashi A, Hirochika H, Takatsuji H. 2015. Abiotic stresses antagonize the rice defence pathway through the tyrosine-dephosphorylation of OsMPK6. PLoS Pathogens 11: e1005231.</Citation></Reference><Reference><Citation>Vetukuri RR, Whisson SC, Grenville-Briggs LJ. 2017. Phytophthora infestans effector Pi14054 is a novel candidate suppressor of host silencing mechanisms. European Journal of Plant Pathology 149: 771-777.</Citation></Reference><Reference><Citation>Vleeshouwers VGAA, Raffaele S, Vossen JH, Champouret N, Oliva R, Segretin ME, Rietman H, Cano LM, Lokossou A, Kessel G et al. 2011. Understanding and exploiting late blight resistance in the age of effectors. Annual Review of Phytopathology 49: 507-531.</Citation></Reference><Reference><Citation>Wang X, Boevink P, McLellan H, Armstrong M, Bukharova T, Qin Z, Birch PR. 2015. A host KH RNA-binding protein is a susceptibility factor targeted by an RXLR effector to promote late blight disease. Molecular Plant 8: 1385-1395.</Citation></Reference><Reference><Citation>Wang YJ, Li JF, Hou SG, Wang XW, Li YA, Ren DT, Chen S, Tang XY, Zhou JM. 2010. A Pseudomonas syringae ADP-ribosyltransferase inhibits Arabidopsis mitogen-activated protein kinase kinases. Plant Cell 22: 2033-2044.</Citation></Reference><Reference><Citation>Yang KY, Liu YD, Zhang SQ. 2001. Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proceedings of the National Academy of Sciences, USA 98: 741-746.</Citation></Reference><Reference><Citation>Yang L, McLellan H, Naqvi S, He Q, Boevink PC, Armstrong M, Giuliani LM, Zhang W, Tian Z, Zhan J et al. 2016. Potato NPH3/RPT2-like protein StNRL1, targeted by a Phytophthora infestans RXLR effector, is a susceptibility factor. Plant Physiology 171: 645-657.</Citation></Reference><Reference><Citation>Yin JL, Gu B, Huang GY, Tian Y, Quan JL, Lindqvist-Kreuze H, Shan WX. 2017. Conserved RXLR effector genes of Phytophthora infestans expressed at the early stage of potato infection are suppressive to host defense. Frontiers in Plant Science 8: 2155.</Citation></Reference><Reference><Citation>Zhang J, Li W, Xiang T, Liu Z, Laluk K, Ding X, Zou Y, Gao M, Zhang X, Chen S et al. 2010. Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host & Microbe 7: 290-301.</Citation></Reference><Reference><Citation>Zhang J, Shao F, Li Y, Cui H, Chen L, Li H, Zou Y, Long C, Lan L, Chai J et al. 2007. A Pseudomonas syringae effector inactivates MAPKs to suppress PAMP-induced immunity in plants. Cell Host & Microbe 1: 175-185.</Citation></Reference><Reference><Citation>Zhang Z, Wu Y, Gao M, Zhang J, Kong Q, Liu Y, Ba H, Zhou J, Zhang Y. 2012. Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. Cell Host & Microbe 11: 253-263.</Citation></Reference><Reference><Citation>Zhang ZB, Liu YN, Huang H, Gao MH, Wu D, Kong Q, Zhang YL. 2017. The NLR protein SUMM2 senses the disruption of an immune signaling MAP kinase cascade via CRCK3. EMBO Reports 18: 292-302.</Citation></Reference><Reference><Citation>Zheng X, McLellan H, Fraiture M, Liu X, Boevink PC, Gilroy EM, Chen Y, Kandel K, Sessa G, Birch PR et al. 2014. Functionally redundant RXLR effectors from Phytophthora infestans act at different steps to suppress early flg22-triggered immunity. PLoS Pathogens 10: e1004057.</Citation></Reference><Reference><Citation>Zheng X, Wagener N, McLellan H, Boevink PC, Hua C, Birch PRJ, Brunner F. 2018. Phytophthora infestans RXLR effector SFI5 requires association with calmodulin for PTI/MTI suppressing activity. New Phytologist 219: 1433-1446.</Citation></Reference><Reference><Citation>Zhou J, Wu S, Chen X, Liu C, Sheen J, Shan L, He P. 2014. The Pseudomonas syringae effector HopF2 suppresses Arabidopsis immunity by targeting BAK1. The Plant Journal 77: 235-245.</Citation></Reference><Reference><Citation>Zipfel C. 2008. Pattern-recognition receptors in plant innate immunity. Current Opinion in Immunology 20: 10-16.</Citation></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Du, Yu" sort="Du, Yu" uniqKey="Du Y" first="Yu" last="Du">Yu Du</name></noRegion><name sortKey="Chen, Xiaokang" sort="Chen, Xiaokang" uniqKey="Chen X" first="Xiaokang" last="Chen">Xiaokang Chen</name><name sortKey="Guo, Yalu" sort="Guo, Yalu" uniqKey="Guo Y" first="Yalu" last="Guo">Yalu Guo</name><name sortKey="Huang, Guiyan" sort="Huang, Guiyan" uniqKey="Huang G" first="Guiyan" last="Huang">Guiyan Huang</name><name sortKey="Huang, Guiyan" sort="Huang, Guiyan" uniqKey="Huang G" first="Guiyan" last="Huang">Guiyan Huang</name><name sortKey="Li, Fangfang" sort="Li, Fangfang" uniqKey="Li F" first="Fangfang" last="Li">Fangfang Li</name><name sortKey="Meng, Yuling" sort="Meng, Yuling" uniqKey="Meng Y" first="Yuling" last="Meng">Yuling Meng</name><name sortKey="Shan, Weixing" sort="Shan, Weixing" uniqKey="Shan W" first="Weixing" last="Shan">Weixing Shan</name><name sortKey="Zhang, Houxiao" sort="Zhang, Houxiao" uniqKey="Zhang H" first="Houxiao" last="Zhang">Houxiao Zhang</name><name sortKey="Zhang, Xiaojiang" sort="Zhang, Xiaojiang" uniqKey="Zhang X" first="Xiaojiang" last="Zhang">Xiaojiang Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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